Search Equipment

Dataset

Optum Clinformatics Data Mart

Optum’s de-identified Clinformatics® Data Mart Database (CDM) is a statistically-deidentified, HIPAA-complaint, closed system of administrative health claims composed of members with commercial and Medicare Advantage plans and includes claims for about 67 million people from all 50 U.S. states.

Dataset

Safegraph (cell device mobility data)

These are data collected from (many dozens of millions of ) cell devices that show movements across space and time. For an overview of the use of these kinds of cell data, please see https://www.ashecon.org/activities/ashecon-appam-webinar-cellular-mobility-data-what-is-it-and-how-can-it-be-used-for-research/ & See https://www.safegraph.com/covid-19-data-consortium for details on this data resources and see

Dataset

NielsenIQ - Consumer Panel Data

The Consumer Panel Data comprise a panel about purchases in a longitudinal study. Panelists use in-home scanners to record all of their purchases intended for personal use. Consumers provide information about their households and what products they buy, as well as when and where they make purchases. Only tenured & tenure-track faculty, PhD students, and postdoctoral researchers are eligible for an account. Register: https://marketingdata.chicagobooth.edu/Anonymous/Welcome Bloomington Only.

Dataset

NielsenIQ - Retail Scanner Data

Retail Scanner Data consist of weekly pricing, volume, and store environment information generated by point-of-sale systems from more than 90 participating retail chains across all US markets. Only tenured & tenure-track faculty, PhD students, and postdoctoral researchers are eligible for an account. Register: https://marketingdata.chicagobooth.edu/Anonymous/Welcome Bloomington Only.

Dataset

Nielsen - Ad Intel Data

Nielsen's Ad Intel Data cover advertising occurrences for a variety of media types across the US, starting in 2010. These data can be broken down by Market Code (i.e., ~200 Designated Market Areas (DMAs), which can be matched to DMAs in the Consumer Panel and Retail Scanner datasets). Only tenured & tenure-track faculty, PhD students, and postdoctoral researchers are eligible for an account. Register: https://marketingdata.chicagobooth.edu/Anonymous/Welcome Bloomington Only.

Dataset

CoreLogic Tax and Deed Data

CoreLogic is a leading property information & analytics provider. The company’s data from public, contributory and proprietary sources includes over 4.5 billion records spanning more than 50 years. Property Tax Records: Over 150 million Residential and Commercial property records collected from 99.7% of U.S. County Tax Assessor, Collector and Treasurer offices. Deed Records: More than 850 million historical real estate transactions from over 3,000 County Clerk/Recorder offices.

Dataset

CoreLogic Loan-Level Market Analytics (LLMA)

Mortgage origination and performance data which has been contributed by servicers and spans the life of each residential loan. It includes data on loan origination, loan performance, and inferred and contributed loan modification data. Data from 1990s.

Dataset

CoreLogic Non-Agency RMBS (NARMBS)

Dataset covers almost $1 Trillion in non-agency residential mortgage backed securities with over 95% of outstanding pool balances, provides detailed loan-level information on underlying collateral on over 16,500 private issue mortgage-backed securities.

Software

Microsoft Endpoint Configuration Manager

Deployment/ patch and configuration manger software for managing windows endpoint computers

Software

BeyondTrust Remote Support

BeyondTrust Remote Support offers the ability to connect to devices running Windows, MacOS, and Linux operating systems to view and/or control the remote computer using secure, logged connections.

Dataset

HCUP-Nationwide Inpatient Sample

Approximately 20% sample of hospitalizations in the U.S., 1988 and onwards. Please see more details at https://www.hcup-us.ahrq.gov/db/nation/nis/nisdbdocumentation.jsp Available at no cost to additional users at IU. We are able to onboard new users and assist them in completing their own data use agreement. New users will not need to pay fees as long as they are IU researchers.

Software

PhysiCell

C++ based open source agent-based modeling software for biological systems. Simulate individual cells as they interact in 2D and 3D tissue environments. Software has been applied to broad problems in cancer biology, immunology, infectious diseases, microbial ecosystems, cryobiology, developmental biology, and other areas. Download: https://github.com/mathcancer/physicell Recent training materials: https://github.com/PhysiCell-Training/ws2021

Dataset

AllofUs

IU is a site through which researchers can use the database AllofUs (https://allofus.nih.gov/) The All of Us Research Program is an ambitious effort to gather health data from one million or more people living in the United States to accelerate research that may improve health.

Dataset

CRC/Sidus Real World Evidence Cardiology Dataset

The CRC/Sidus Real World Evidence (RWE) Cardiology Dataset is a de-identified, HIPAA-complaint, closed system of ambulatory, community-based Electronic Health Records. Data has been collected from large Cardiology Specialty Groups (546 Specialty-based Providers, 21 Large Cardiology Installations) across the United States for over two decades. Structured Data includes 56 million Labs, 12 million Clinical Notes, 32 million Diagnosis, 15 million Medications and 12 million Procedures.

Equipment

4D-Nucleofector System

The controlling unit of the 4D-Nucleofector® System is suited to handle various functional units for efficient transfection of hard-to-transfect cell lines and primary cells in different formats.

Equipment

Agilent 1200 HPLC and Agilent 6130 MSD

The instrument is a high performance liquid chromatograph with a quadrapole mass spectrometer that can utilize electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) for organic reaction monitoring, quantitative LC/MS, and air-sensitive compound characterization.

Equipment

Agilent 1290 Infinity II LC and Agilent 6135 LC MS XT

Ultra high pressure liquid chromatograph connected to a single quadrupole electrospray ionization source for organic reaction monitoring, high through-put nominal mass screening, and quantitative LC-MS.

Equipment

Agilent 6890N GC and Agilent 5973 Inert MSD

This instrument is a gas chromatograph with a quadrupole mass spectrometer using electron ionization (EI) for organic chemistry reaction monitoring, and analysis of volatile products at sub-ambient oven temperatures.

Equipment

Agilent 6890N GC and Agilent 5973 Inert MSD with a Gerstel MPS and TDS

The 8690N-5973 MSD is a gas chromatograph with a quadrupole mass spectrometer using electron ionization. The multipurpose sampler allows for automated sample preparation and introduction while the thermal desorption system allows analysis of trapped volatile and semi-volatile organics and headspace sampling of volatile reaction products. The system is also used for targeted GC/MS metabolomics and organic reaction monitoring by GC/MS.

Equipment

Agilent 7890B GC and Agilent 5977B MSD

This instrument is a gas chromatograph with a quadrupole mass spectrometer utilizing electron ionization(EI) for targeted metabolomics assays, untargeted quantitative GC-MS, and reaction monitoring.

Equipment

Agilent 7890N GC and Agilent G7250 Q-TOF

This instrument is an gas chromatograph with a quadrupole time of flight mass spectrometer utilizing electron ionization (EI) at either 15V or 70V for formula confirmation by accurate MS, untargeted metabolomics after derivatization, complex mixture GC/MS using accurate MS, and stable isotope labeled fluxomics.

Equipment

Akoya CODEX imaging system

Akoya CODEX imaging system is an integrated robotic fluidics and fluorescence imaging system that supports multiplexed fluorescence imaging of 40+ probes in the same sample, using a proprietary process of repeated sequential imaging and stripping of fluorescently-labeled DNA-barcode probes.

Equipment

AKTA Pure HPLC

This is an HPLC for the fractionation, separation and purification of biological molecules. I contains an autosampler and fraction collector to enable automated processing of multiple samples

Equipment

Alchemist

Protein crytallization solution/screen mixer.

Equipment

ALPAO

Continuous reflective surface motioned by magnetic actuators that has large strokes, high dynamic motion and an excellent optical quality to measure wavefront correction.

Equipment

AO- OCT Retina Camera

Retina Camera.

Equipment

Atomic Force Microscope

The MFP-3D integrates optical microscopy and atomic force microscopy (AFM). Sample features are located using brightfield, phase contrast, or fluorescence, then probed at the nanometer scale with an AFM scan. AFM is combined with such powerful optical microscopy techniques as confocal microscopy, including the capability to synchronize with confocal measurements. The superluminescent diode and additional optics minimize interference with fluorescent signals. Advanced software capabilities allow the researcher to display results intuitively in 3D, then use powerful analysis and scripting tools to extract and graph quantitative information.

Equipment

Avanti Centrifuge

High speed/high capacity general use centrifuge.

Equipment

B600 NMR Spectrometer

State-of-the-art 600 MHz NMR spectrometer for structure and dynamics study of biological molecules in solution.

Equipment

BD FACSAria IIu

High-speed cell sorter capable of analyzing 17 parameters including up to 14 colors.

Equipment

BD LSRII

High-speed 4 laser flow cytometry analyzer, capable of multi-color analysis of up to 13 colors and up to 16 parameters detection.

Equipment

BD Pathway 855

The Pathway 855 is a versatile system for high-content imaging of live or fixed samples. It can handle specimen formats from single slides to multiwell plates. It can automatically image multiple sites per slide or well and every well of a multiwell plate.

Equipment

BeamWorks Spark 400

Electronics Selective Assembly/Rework robot.

Equipment

Beckman XPN Preparative Ultracentrifuge

These floor model preparative ultracentrifuges are capable of spinning up to 40 different rotors to speeds of 100,000 rpm (802,000 x g) for pelleting of samples. Also possible are zonal and continuous flow separation methods with precise speed and temperature control. Beckman swinging bucket rotors (SW41, SW32) or fixed angle rotors (70Ti, and 100Ti) are available for sample preparations.

Equipment

Bio-Rad Radiance

Microscope.

Equipment

Biomek FXP Lab Automation Workstation Function

Automated plate duplicationÊAssay automation.

Equipment

BookEye

Bookeye 5 V1A Professional Book Scanner

Equipment

Bruker Autoflex III Smartbeam MALDI-TOF MS

This instrument is a matrix-assisted laser desorption/ionization reflectron time of flight mass spectrometer used for analysis of polymers, peptides, oligonucleotides, or proteins.

Equipment

Carbon Evaporation and Sputter Coating

This tool can be used to coat samples with metals and carbon. This includes usage that ranges from SEM sample preparation to fabrication. Standard coating materials include carbon (via carbon evaporation), Gold (via sputtering), and Copper (via sputtering). Note, other targets can be purchased to allow the sputtering of other metals. This instrument does have an associated user fee to help cover the cost of consumables.

Equipment

CD Jasco J-715

Circular Dichroism Spectropolarimeter.

Equipment

Clearwave Contact Lens Wavefront Based Production Metrology Unit

The ClearWave Contact Lens Precision Aberrometer system combines the world's highest resolution Shack-Hartmann wavefront sensor with a custom designed software package to provide superior insight into the performance and production of contact lenses. ClearWave includes an extraordinarily high dynamic range and resolution Shack-Hartmann wavefront sensor so you can profile contact lenses with extreme accuracy.

Equipment

Complete Ophthalmic Analysis System (COAS) G100

Opthalmic wavefront system.

Equipment

Complete Ophthalmic Analysis System (COAS) G250 MODEL 2800

High Resolution Opthalmic Aberrometer Including Power Table, Support Computer,Positioning Stage And Software.

Equipment

Confocal Microscope

This confocal microscope can be used to image fixed and living samples. It can provide brightfield, differential interference contract (DIC), widefield, and confocal images. With an array of available laser lines, it is capable of multi-labeled imaging (up to four fluorophores simultaneously). The scope can operate in up to 4D imaging (i.e., 3D imaging over time). With respect to live cell imaging and living samples in general, an available stage incubator can facilitate imaging over a period of days. Aside from imaging, it is also equipped for Förster resonance energy transfer (FRET) and fluorescence recovery after photobleaching (FRAP) experiments.

Equipment

Cryostat

This Leica cryostat is used to section frozen tissues from 10-60 microns.

Equipment

DAWN HELEOS II (MALS) / OptiLab rEX

Multi-angle Light Scattering Instrument and Refractive Index Detector

Equipment

Dynamic Light Scattering and Zeta Potential

This tool can be used to characterize colloids and nanoparticles, macromolecules, proteins, and more in solution. Capabilities include measuring particle size, molecular size, and surface charge. Together, this allows researchers to develop and optimize nanoparticle synthesis processes, determine stability, investigate particle functionalization and coatings, and much more.

Equipment

Echo Revolve Microscope

Microscope that can take images of brightfield, phase contrast, and IF (red, blue, green) images of live or fixed cells. Uses a digital image either inverted or upright. 10-100X. Does z-stack and quantification of staining.

Equipment

Electron Microprobe

To determine the concentrations of elements in solid materials such as minerals and glasses.

Equipment

EMX EPR Spectrometer

X-band CW EPR Spectrometer for studying molecules that contain unpaired electrons, typically transition-metal ions and organic radicals, yielding structural and dynamic information.

Equipment

EnSpire

The EnSpire is a very sensitive multimodal plate reader.

Equipment

expoCube

The ExpoCube is a novel Air Liquid Interface (ALI)/Transwell in vitro exposure system which permits highly reliable and effective deposition of aerosols onto cells and tissues.

Equipment

Field Emission Scanning Electron Microscope

This high resolution JEOL7800F Field Emission Electron Microscope is equipped with detectors to support topographical imaging, compositional imaging, and quantitative elemental analysis. The facility is equipped with basic preparation tools as well as a carbon evaporation and gold sputtering capabilities. This equipment has an associated user fee and INDI's Operations Manager provides technical support, technician sample running, and user training.

Equipment

Flexstation 3

The FlexStation3 is a robotic fluorescent plate reader with fast data capture for real time kinetic detection. Can be used for measurement of membrane potential, calcium release and intracellular pH.

Equipment

Fluorescent lifetime imaging microscope

this is a time-resolved fluorescent imaging system for recording fluorescent lifetime simultaneously with the intensity. The instrument can perform the FLIM-FRET imaging, single molecule spectroscopy, such as FCS.

Equipment

Focused Ion Beam

The focused ion beam (FIB) instrument is used particularly in the semiconductor and materials science fields for site-specific analysis, deposition, and ablation of materials.ÊThe FIB instrument uses a focused beam of ions, e.g., Ga ions, and is incorporated in a system with both electron and ion beam columns, allowing the same feature to be investigated using either or both beams. Source ions are then accelerated to an energy of 5-30 keV (kiloelectronvolts), and focused onto the sample by electrostatic lenses. When the high-energy gallium ions strike the sample, they will sputter atoms from the surface. Because of the sputtering capability, the FIB is used as a micro-machining tool, to modify or machine materials at the micro- and nanoscale. The common smallest beam size is 2.5-6 nm.

Equipment

FutureSystems

Computer systems optimized for Big Data research and analysis. Supports Hadoop, Spark and Twister2 with solid-state disk, NVMe and local HDD.

Equipment

GE DeltaVision eDV

The GE Elite DeltaVision Live Cell Imaging System is optimized for deconvolution microscopy. Deconvolution is a software technique that mathematically de-blurs images. This system features a very nice motorized stage for precise control of X, Y, and Z plane movements. Multiple sites on a slide can be marked and revisited.

Equipment

GE DeltaVision pDV

The GE Personal DeltaVision Live Cell Imaging System is optimized for deconvolution microscopy. Deconvolution is a software technique that mathematically de-blurs images. This system features a very nice motorized stage for precise control of X, Y, and Z plane movements. Multiple sites on a slide can be marked and revisited.

Equipment

Gel Permeation Chromatography

The Waters Breeze gel permeation chromatography (GPC) system is a standalone HPLC instrument dedicated to characterizing the molecular weight and molecular weight distribution (MWD) of polymers. It consists of a 1525 binary HPLC pump, a 1500 column heater, a manual injector, an inline degasser AF, a 2414 refractive index detector and a 2487 dual _ absorbance UV/Vis detector. With the installed three Styragel high resolution columns (HR2, HR4 and HR5, 7.8_300 mm) that are connected together, it is capable of measuring molecular weight in the range of 10E2 Ð 10E5. The GPC columns are compatible with THF. THF is the default eluent. The polymer samples must have a good solubility in THF.

Equipment

Ground Conductivity Meter

EM34-3GROUND CONDUCTIVITY METER--

Equipment

Gryphon LCP

Protein and crystallization solution drop setter robot.

Equipment

Heidelberg Spectralis Tracking OCT 2 Optical Imaging System

The SPECTRALIS¨ OCT2 Module is the next generation OCT technology for the SPECTRALIS platform, offering enhanced image quality from vitreous to choroid. With a fast scanning speed of 85,000 Hz, it improves clinical workflow and increases patient comfort by shortening examination times.

Equipment

High Pressure Freezer

Rapid freezing of samples to be further processed for electron microscopy.

Equipment

HRT3 PowerCheck Cornea

Retinal Imaging.

Equipment

I400 NMR Spectrometer

400 MHz NMR spectrometer for structural elucidation, molecular dynamics and reaction kinetic study of small molecules in solution.

Equipment

I500 NMR Spectrometer

500 MHz NMR spectrometer for structural elucidation, molecular dynamics and reaction kinetic study of small molecules in solution.

Equipment

I600 NMR Spectrometer

State-of-the-art 600 MHz NMR spectrometer for structural elucidation, molecular dynamics and reaction kinetic study of small molecules in solution.

Equipment

Illumina MiSeq

\Next-generation"sequencing."""

Equipment

Illumina NextSeq500 sequencer

High-throughput \next-generation"sequencing for genomics studies."""

Equipment

Image Analysis Workstations

Four computer workstations, each with multicore Xeon processors, up to 256 GB video RAM, and up to 128 GB of system memory run a variety of image processing software (Metamorph, ImageJ, Autoquant, Imaris, Halo, Fluorender and the CODEX software suite) as well as Adobe Photoshop and Premiere to support preparation of publication-quality figures and videos. All microscopy systems and computers are connected to a 1000Base-TX Ethernet switch.  The ICBM is also supported by the supercomputing infrastructure provided by Indiana University. 

Equipment

In-Vivo Imaging Core

The In-Vivo Imaging Core provides imaging services for clinical trial, observational and preclinical studies. The core also provides radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, CT scanners, Bruker 9.4T preclinical PET-MRI scanner, a Medical Cyclotron and Radiochemistry Facilities. Highly skilled faculty and staff are available to assist with research study designs. We are located at the Research 2 building, Goodman Hall, and neuroscience building.

Equipment

Integral Optical Coherence Tomography

Allows detailed cross-sectional images of structures of the eye and can image the cornea, iris, lens, vitreous, retina and choroid.

Equipment

ISS Alba Fast FLIM microscope system

ISS Alba Fast FLIM system is a high-speed fluorescence imaging system that supports frequency-domain-based fluorescence lifetime imaging, fluorescence correlation microscopy and PIE. It is mounted on an Olympus IX71 microscope stand equipped with Olympus 10x/0.4, 20x/0.75, 40x/1.3 oil, and 60x/1.2W objective lenses coupled to a piezo stepper motor. The ISS FastFLIM system is coupled to the Alba LCSM. The lasers (10mW 405nm and 5mW 448nm diode lasers, and a 200 mW Supercontinuum White Light Laser) are modulated by the FastFLIM system at frequencies of 10 MHz or higher, and measurements can be analyzed using multiple digital harmonics. FRET FLIM measurements can be acquired for cyan, green or yellow donor probes, and the donor/acceptor signals are detected with two identical APDs. The APDs are capable of single-molecule detection, and the system is equipped with the ISS Alba FCS module. This enables one channel FCS or two channel cross-correlation FCS (FCCS). The ISS VistaVision firmware is also optimized for pulsed interleaved excitation (PIE) that enables crosstalk-free measurements of FCCS and measurements for FRET-FLIM from two independent probes simultaneously. The IS VistaVision software is used for phasor analysis of the FLIM measurements. The system is equipped with a stage-top environmental control system maintaining live specimen at 37º C and 5% CO2

Equipment

JEOL JEM 1010

100 kV transmission electron microscope for biological and material science specimens.

Equipment

JEOL JEM 1400plus

120 kV transmission electron microscope for imaging biological and material science specimens.

Equipment

JEOL JEM 3200FS

300 kV transmission electron microscope with scanning transmission EM (STEM) capabilities.

Equipment

Keyence BX800 microscope system

Specify the functioKeyence BX800 microscope system is an automated high-content imaging system with advanced automated image collection and analysis capabilities, supporting a variety of cellular and biochemical assays of living or fixed specimens mounted in dishes, flasks, multi-well plates, and microscope slides or chambers. System supports imaging in fluorescence, brightfield, and oblique illumination with a highly sensitive, cooled CCD camera and a built-in darkroom, generating publication-quality images . It is equipped with DAPI, GFP, RFP, Cy5, and Cy7 epi-filter cubes, 4x/0.1, 10x/0.3, and 20x/0.75 objectives, automated stage, and a stage-top environmental incubation system supporting time-lapse imaging of live cells. Automated quantification can be performed with the Keyence analysis application augmented with three additional module licenses (Hybrid Cell Count, Time-lapse, Advanced Observation). n

Equipment

KinTek SF-300X Stopped Flow Spectrometer

Fast reaction kinetics.

Equipment

Leica M205FA Stereo Microscope

This is an excellent microscope for a wide range of uses - from specimen preparation and screening to high-resolution imaging of a wide range of samples. It is equipped for brightfield and epifluorescense imaging.

Equipment

Leica SP5 laser scanning confocal

The SP5 is a versatile scanning confocal microscope. This system has 4 detectors enabling the simultaneous imaging of up to 4 different wavelengths. It has 3 lasers providing 7 excitation wavelengths and a prism spectrometer to control emission wavelengths to make this a very versatile system compatible with most combinations of fluorophores.

Equipment

Leica SP8 laser scanning confocal

A versatile scanning confocal microscope. It is also set up to do Fluorescence Lifetime Imaging (FLIM) and Fluorescence Correlation Spectroscopy (FCS).

Equipment

Leica TCS SP8 confocal/multiphoton microscope

Leica TCS SP8 Resonant-scanning confocal/multiphoton microscope is configured for both multiphoton and confocal imaging on an upright stand. Confocal fluorescence excitation at 405, 448, 488, 552 and 633 nm with multiphoton fluorescence excitation provided by a Spectra-Physics MaiTai DeepSee titanium-sapphire laser, providing tunable illuminations from 690 to 1040nm. The system is configured with 4 internal (descanned) PMTs and 4 external (non-descanned) detectors – 2 PMTs and 2 HyD hybrid detectors. The SP8 MP includes both standard galvanometric scanning for imaging at up to 1800 Hz and resonant scanning for imaging up to 8000 Hz, supporting full frame imaging at up to 30 fps.  The automated stage supports automatic time lapse studies of multiple fields and tile acquisitions.

Equipment

Leica TCS SP8 Dive confocal/multiphoton microscope

Leica TCS SP8 Dive confocal/multiphoton microscope has confocal capabilities equivalent to those of the system described above, but is mounted on an inverted stand. This system is also equipped with several features that extend our capabilities for intravital microscopy. First, it is equipped with two IR lasers, a Spectraphysics MaiTai DeepSee laser and a Spectraphysics Insight laser system that extends multiphoton excitation out to 1300 nm, improving intravital microscopy of red fluorescent proteins. The two-laser system also facilitates simultaneous excitation of multiple, spectrally separated probes. Second, this system is configured with 4 spectral detectors on the non-descanned pathway (2 PMTs and 2 HyD detectors), improving detection and distinction of multiple probes. Finally, this system is equipped with a two channel 2-photon ISS Fast FLIM fluorescence lifetime system and a motorized stage supporting tile acquisitions and time-lapse multiple filed studies.

Equipment

Lynx Model 495LX cage and rack washer

Used for efficient cleaning of cages, racks, debris pans, and miscellaneous items for laboratory care.

Equipment

M200 NMR Spectrometer

200 MHz NMR spectrometer for structure and dynamics study of small molecules in solution. It's used for undergraduate organic chemistry classes.

Equipment

Makino

Wire EDM.

Equipment

Microscope

For brightfield, polarized, and fluorescent microscopy.

Equipment

Milltronics

CNC milling machine.

Equipment

Miltenyi MACSQuant VYB

Flow cytometry 3-laser, 8-color analyzer - mobile (on-a-cart).

Equipment

minstrel

Imaging system and Gallery 700 incubators.

Equipment

Moe Cluster

Storage and computing cluster supporting Twitter data collection powering various tools and APIs that are part of the Observatory on Social Media (OSoMe.iuni.iu.edu).

Equipment

Molecular Devices IXM XLS microscope

Molecular Devices IXM XLS microscope system is an automated high-content imaging system with advanced automated image collection and analysis capabilities, supporting a variety of cellular and biochemical assays of living or fixed specimens mounted in dishes or multi-well plates.

Equipment

Monolith NT.115

Microscale thermophoresis.

Equipment

MRI Facility

The Imaging Research Facility (IRF) at Indiana University is a state-of-the-art neuroimaging facility that supports research on brain structure and function and their relation to behavior and cognition.

Equipment

Multi-mode Plate Reader Synergy H1

Top and bottom fluorescence intensity, UV-visible absorbance and luminescence detection.

Equipment

Multipurpose Diffractometer

Powder diffraction, non-ambient posder diffraction.

Equipment

Nanoimprint Lithography

Nanonex NX2500 is a nanoimprint system with front-side alignment for maximum 4Ó wafer. It has both thermal nanoimprint module and UV nanoimprint module. There two modules could be operated separately or simultaneously. The UV LED light has dual wavelength of ~365 nm and ~395 nm.The non-contact radiant heating and high-efficiency integrated air cooling technologies allow rapid heating and cooling of samples. NX2500 utilizes patented air cushion press (ACP) technique that enables ultimate nanoimprint uniformity. The smart sample holder could handle samples with different sizes (up to 4 inch diameter) and irregular shapes. The high-precision optical alignment module allows sub-micron overlay alignment accuracy.

Equipment

NanoITC

Isothermal Titration Calorimetry

Equipment

Nanoparticle Tracking Analyzer

Equipment

Neurolucida

The Neurolucida is a wide-field Nikon microscope for performing detailed morphometric analysis of neurons, such as quantifying branching structures and creating detailed anatomical models.

Equipment

Nikon A1 Scanning Confocal/ TIRF microscope

A versatile system is built on the Nikon Eclipse Ti inverted microscope. It is a nice scanning confocal, a TIRF system, and a high-content imaging system in one package.

Equipment

Nikon live cell imaging system

Nikon live cell imaging system is configured for high-speed imaging of living samples.   Built around an inverted Nikon Eclipse Ti stand, it supports both confocal and widefield imaging.  Confocal microscopy is based upon a Yokogawa CSU-X1 spinning disk, with laser illumination provided at 442, 488, 514 and 561 nm via an Agilent launch with images collected using a Photometrics Prime 95B Scientific CMOS.  Widefield epifluorescence microscopy can be conducted using a Xenon lamp source, with optics suitable for excitation from 340 nm to 700 nm, with images collected by a Hamamatsu Orca Flash 4.0LT Scientific CMOS. It is equipped with a Perfect Focus system, a motorized stage that supports automatic time course studies of multiple fields and a stage-top incubator for maintaining a heated and CO2 dependent environment to ensure stable long term imaging of cultured cells.

Equipment

Nikon NiE

The Nikon NiE is a very nice general purpose research microscope. It is equipped for brightfield, DIC, phase and epifluorescence imaging. The microscope has 4X to 100X objectives so a wide range of samples can be accommodated. Epifluorescence imaging on this scope works best with thin, flat specimens.

Equipment

Octet Red K2

Bio-Layer Interferometry (BLI) to measure binding interactions.

Equipment

Odyssey

This near-IR scanner can be used for Western detection, cell-based assays, small animal, tissue, and slide imaging.

Equipment

Okuma

CNC lathe.

Equipment

Olympus Fluoview 1000 MPE confocal/multiphoton

Olympus Fluoview 1000 MPE confocal/multiphoton microscope system supports both confocal and multiphoton microscopy. Fluorescence emissions may be collected either with internal (descanned) detectors (one photomultiplier tube and two spectral detectors) or with a 4-channel external (non-descanned) detector module. Confocal fluorescence excitation is provided at 405, 488, 515, 559 and 635 nm and multiphoton fluorescence excitation is provided by a Spectraphysics DeepSee tunable titanium-sapphire laser, providing tunable illuminations from 710 to 990nm. The system is mounted on an IX-81 inverted microscope stand and is equipped with an automated stage, supporting automatic time course studies of multiple fields and tile acquisitions.

Equipment

Olympus OSR Spinning Disk Confocal

High-resolution to super-resolution confocal imaging of live cell samples.The OSR microscope achieves super resolution by combining superior optics with the new Yokogawa W1 Spinning Disk to improve signal and reduce noise. In super resolution mode, Airy disk oversampling drives resolution down to 120 nm by capturing subtle high-frequency special components not visible in conventional spinning disk microscopy.

Equipment

OMX-SR 3D-SIM Super-Resolution system

Offering resolution at twice the diffraction limit of traditional microscopes, the OMX system is the practical solution for three dimensional super resolution imaging that does not depend on special fluorophores. The OMX is also set-up for TIRF and fast conventional imaging of live cells.

Equipment

Optima Ultra Centrifuge

Used for ultra-high speed centrifugation.

Equipment

Orbitrap Fusion Lumos

This mass spectrometer is equipped with a nano-scale LC system. It is used for high coverage proteomics experiments. It is capable of sequencing and quantifying proteins and post-translational modifications on proteins/peptides.

Software

Pages

Pages is a web hosting service that allows an individual's professional, research, instructional, or academic web content to be published. The service is available to current students, faculty, and staff. Each Pages account is assigned to an individual IU username and must be maintained by the account owner.

Equipment

PERFACTORY 3 MINI SXGA

3D printer (three dimensional Rapid Prototype Manufacturing System).

Equipment

Phoenix DT

Protein and crystallization solution drop setter robot.

Equipment

Plasma Cleaner

Cleans electron microscopy holders, grids and other small parts using a argon/oxygen plasma.

Equipment

Profilometer

Scans and analyzes profile of object's surface. Uses white light source and and is non-contact.

Equipment

QuantStudio 7 Flex

Real-time qRT-PCR system used to track changes in mRNA expression levels.

Equipment

Raman Spectroscopy

This non-destructive and non-contact tool is capable of imaging and producing detailed chemical fingerprints of samples. This is a confocal system and can therefore provide these results at high spatial resolution. It is fast, requires little if any sample preparation, and is capable of sub-micron scale analysis.

Equipment

Retina Angiograph ICG Fluorescein with Joystick

Intended use is for the examination of the retina by laser scanning either with or without contrast agent, resp. fluorescence agent). The purpose of the angiography testing is to assist in the diagnosis of eye diseases. The diagnostic result shall provide help to the physician for adequate therapy.

Equipment

Retinal Microperimeter

Nidek MP-1 Retinal Microperimeter.

Equipment

RT-PCR

Real Time PCR System for SNP genotyping, gene expression analysis, microRNA expression, protein expression, translocation analysis, gene detection, and viral load analysis.

Equipment

Scanning Electron Microscope

The Quanta 600F scanning electron microscope (SEM) is a versatile, high-performance instrument with three modes (high vacuum, low vacuum, and environmental) to accommodate the widest range of samples of any SEM system. The SEM system is equipped with an energy dispersive spectrometer and electron backscatter detector. In addition, the field emission gun (FEG) system contains a S/TEM detector for bright-field and dark-field sample imaging. The motorized stage has 150 mm of travel in the X and Y directions and 60 mm of travel in the Z direction. The SEM is also equiped with a Nabity lithography system to fabricate nanostructures down to sub 50 nm.

Equipment

Scanning Laser Ophthalmoscope

Scanning laser ophthalmoscopy is a method of examination of the eye. It uses the technique of confocal laser scanning microscopy for diagnostic imaging of retina or cornea of the human eye.

Equipment

Sciex 4000 QTrap/Agilent 1290 Infinity II UHPLC

Sciex 4000 QTRAP is a hybrid triple quadrupole/LIT (linear ion trap) mass spectrometer. The Q3 region can be operated as either a standard quadrupole mass spectrometer or as a linear ion trap mass spectrometer. The QTRAP is connected to an Agilent 1290 Infinity II UHPLC for sample introduction.

Equipment

Scintillation Counter (Packard 1600TR)

Quantitation of assays and substrates

Equipment

SimCapture Audio/Video and Documentation Recording

Record multicamera video and audio with capability of adding additional digital video input devices such as monitor screens. All inputs synchronized into a cloud-based viewing system for viewing anywhere with broadband connection. System is time stamped and allows annotation either live or post recording. Custom documentation forms are possible to generate checklists or other survey tools embedded in the system. Each room features two HD video cameras with full PTZ capabilities, ceiling mounted microphone with two wearable microphones available, and digital video input (HDMI) for other video devices. Resource is located in the Interprofessional Simulation Center in the Health Sciences Building on the Bloomington Regional Academic Health Center campus. Seven separate rooms with video and audio recording are available, each with an observation area with one-way glass window and a separate room for live video viewing. Viewing can also be done remotely. While designed for healthcare education and training, resource can be used for other purposes where synchronized video, audio, and annotation/documentation may be required such as product or prototype testing. Ample electrical outlets, compressed air, medical vacuum, oxygen, variable lighting, and sink with running water in each room. For healthcare product or process testing, multiple beds types are available along with a variety of clinical equipment and supplies. High-technology computer-controlled full-bodied patient simulators are also available. Ideal environment to develop and test healthcare products, but adaptable for other uses.

Equipment

Single crystal diffractometer

Single crystal structure determination.

Equipment

Sony SH800

High-speed cell sorter capable of analyzing 8 parameters including up to 6 colors. Training available.

Equipment

Spectralis Tracking Heidelberg Retina Tomograph (HRT)

Used to exam the posterior segment or the back of the eye and suitable for examining the possibility of glaucoma in a patient.

Equipment

Spectrofluorimeter

The PTI system consist of the QuantaMasterª steady state spectrofluorometer, LaserStrobeª for lifetime and time-resolved spectra collection and Integrating Sphere designed for enhanced measurement of quantum yields of solids, films, and powders.The QuantaMasterª spectrofluorometer is PTIÕs flagship steady state (intensity based) research fluorometer, and is designed for the user who needs the best sensitivity, performance and versatility available. Selected applications: Fluorescence Emission/Excitation scans, Relative and Absolute Quantum Yield, Thin Film and Powder sample measurements, Fluorescence Anisotropy, Kinetic measurements.

Equipment

Spinning disk confocal microscope

This confocal microscope utilizes the combination of a spinning disk and a high resolution camera to visualize the image plane.

Equipment

StepOne Plus qRT-PCR

Quantitative Real-time PCR.

Equipment

Stereo Investigator

The Stereo Investigator is used in performing cell counts and other quantitative analyses in neurobiology. This wide-field microscope is designed to be time efficient and allow semi-automated quantification of histological samples.

Equipment

SuperK Extreme EXR-15, 100Mhz

The range of SuperK EXTREME/FIANIUM supercontinuum white light lasers are broad as a lamp and bright as a laser. They deliver high brightness diffraction limited light in the entire 400-2400 nm region. By adding one of our computer controlled filters, the SuperK can be converted into an ultra-tunable laser with up to 16 simultaneous lines. Our lasers are maintenance free and the fully fiber monolithic architecture ensures excellent reliability and a lifetime of thousands of hours.

Equipment

SYS0024 NOGGIN 250 PLUS SMART CART

SENSORS & SOFTWARE

Equipment

Tabletop Ultracentrifuge (Beckman Coulter Optima)

Equipment

Thermal Evaporator

The Auto 306 FL400 Thin Film Deposition System is set up for sequential evaporation of up to four materials without breaking vacuum. The pumping system incorporates a 540-liter/sec turbo molecular pump backed by an XDS10 dry running primary pump. A rotary work holder is fitted to the chamber top plate. Film thickness is monitored using a Sigma SQM160 quartz crystal film thickness deposition monitor with digital display of deposition rate and deposition thickness. There is the capability to control up to 2 source shutters automatically and close the electromagnetic source shutter when pre-programmed termination thickness values are achieved. Substrate heating is via 500W Quartz lamp heater assembly with lamp.

Equipment

Thermal Gravimetric Analysis

The automated Q5000 is used for complex thermogravimetric analysis (TGA) applications, low-level detection of impurities, kinetic studies, off-gas analysis, and high heating rate operation. Its design integrates a thermobalance engineered for maximum baseline flatness and high sensitivity, with the power and flexibility of an infrared furnace, and a proven horizontal purge gas system. User convenience features include the 25-position autosampler, the integral electromagnet, and software for scheduling automatic calibration, verification and diagnostic tests.

Equipment

Thermo Scientific Finnigan LTQ Orbitrap XL

This instrument is a hybrid mass spectrometer incorporating a linear ion trap and an orbitrap mass analyzer for accurate mass analysis of small molecules for formula confirmation, LC-MS/MS with accurate mass detection, and data dependent LC-MS/MS.

Equipment

Thermo Scientific LTQ Velos

Ion trap mass spectrometer for analysis of peptides and small molecules.

Equipment

Thermo Scientific Orbitrap Fusion Lumos

High mass accuracy mass spectrometer for analysis of peptides, proteins and metabolites. Capable of fragmenting molecules using CID, HCD or ETD.

Equipment

ThermoFisher Talos Artica

200 kV dedicated cryo transmission electron microscope.

Equipment

ThermoFisher Teneo VolumeScope

Scanning transmission electron microscope equipped with a removable ultramicrotome for serial blockface imaging applications.

Equipment

Toothbrushing Simulation Machine

This machine can perform toothbrushing studies to evaluate the abrasivity of test products (e.g. toothpastes, abrasives) according to According to ISO 11609.

Equipment

Typhoon 9500

Variable Mode Imaging System

Equipment

Typhoon FLA9500 Laser Scanner

Specify the functionTyphoon FLA 9500 is a robust and versatile laser scanner that is ideally suited to multiuser environments. Biomolecular imaging applications include sensitive and quantitative measurements of Western blots, multiplex fluorescence, and radioisotopic labels by storage phosphor as well as digitization of colorimetric stains.

Equipment

UB COPAS Select

Large particle sorter (20-350um)

Equipment

Union Biometrica COPAS Select

Large particle sorter.

Equipment

Universal Testing System

Axial tensile and compressive mechanical loading of hard and soft tissues

Equipment

UV Exposure System and Mask Aligner

The OAI model 200 is a mask aligner and UV exposure systems. Utilizing an air bearing / vacuum chuck leveling system, the substrate is leveled quickly and gently, for parallel photomask alignment and uniform contact across the substrate during contact exposure. The system is equipped with a single field Meji microscope and is capable of one micron resolution and alignment precision. The alignment module features a mask insert for a 5 x 5_ mask and a substrate chuck for 4_ square substrates. Up to 6_ diameter substrates can be accommodated with optional tooling. The system can operate in soft contact, hard contact, or vacuum contact modes and the force between the substrate and mask can be adjusted with a user-settable electronic ÔclutchÕ system. The system provides collimated UV light in near UV using a 500W lamp.

Equipment

V8 Brushing Machine

For brushing substrates/dental materials.

Equipment

V800 NMR Spectrometer

State-of-the-art 800 MHz NMR spectrometer for structure and dynamics study of biological molecules in solution.

Equipment

Veritas Micro dissection System

The Veritas is a fully automated microscope system designed to dissect specific cells, organelles, or tissues from your specimen for further analysis. It can do both laser-cutting for a large number of cells and laser capture for single cells or organelles.

Equipment

Visante OCT 2.0

Microscope, OCT.

Equipment

VXR400 NMR Spectrometer

400 MHz NMR spectrometer for structural elucidation, molecular dynamics and reaction kinetic study of small molecules in solution.

Equipment

Waters Synapt G2S

High mass accuracy MS for analysis of proteins, peptides and small molecules.

Equipment

X-Ray Photoelectron Spectroscopy

The PHI VersaProbe II Scanning X-ray Microprobe system is a state-of-the-art Multi-technique instrument. The system provides X-ray Photoelectron Spectroscopy (XPS) wherein samples are irradiated with monochromatic X-rays, causing photoelectrons to be emitted from a surface of a sample. An electron energy analyzer then determines the binding energy of the photoelectrons which provides elemental, chemical state, surface, topographic, bulk chemical and interfacial analysis. The technique is compatible with a range of sample classes.The PHI VersaProbe II employs a unique high flux X-ray source that utilizes a focused electron beam scanned upon an Al anode for X-ray generation and a quartz crystal monochromator that focuses and scans the generated X-ray beam upon the sample surfaces to provide outstanding micro-spectroscopy analytical performance. It is designed for rapid, spatially resolved (micron scale) elemental and chemical analysis of surfaces. The PHI VersaProbe II combines a unique monochromatic X-ray probe with automated sample handling and analysis area identification tools to give true chemical state imaging and multi-point spectroscopy in an automated environment. For sample neutralization, the electron beam scans the anode surface at very high speed to reduce differential charging effects that cause data interpretation problems with non-conductive samples.The PHI VersaProbe II is also equipped with an argon sputtering gun for depth analysis of samples, a hot/cold stage for temperature dependent analyses, and an air-sensitive sample transfer vessel. The instrument is also equipped with Ultraviolet Photoelectron Spectroscopy (UPS) which provides information about the valence region of samples as well as the work function for materials.

Equipment

Zebrafish facility

A fully automated Aquaneering zebrafish facility with 10 racks for approximately 5,000 fish. Temperature, salt and pH controlled and connected RO water equipment.

Equipment

Zeiss Axio Observer Inverted Microscope

Microscope.

Equipment

Zeiss Axio Zoom

Microscope with fluorescence filters for GFP and RFP and a monochromatic camera that can image complete organisms.

Equipment

Zeiss Super Resolution Microscope System

Microscope.

Equipment

Zetasizer

The Zetasizer Nano-ZS can measure (1) particle size of particles and molecules from 0.6 nm to 6 micrometers using non-invasive back-scatter (NIBS) technology and dynamic light scattering, (2) zeta potential in aqueous and non-aqueous dispersions using M3-PALS technology, and (3) molecular weight with an absolute measurement using static light scattering and the sensitivity from an avalanche-photodiode detector and fiber detection optics.

Equipment

Zetasizer Nano-S

Dynamic Light Scattering.